Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires.

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires.

Blog Article

The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare.Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes.The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulated, producing a limited diversity subset.

By statistically analyzing Lamps deep sequencing T-cell repertoire data from twins, unrelated individuals of various ages, and cord blood, we show that T-cell clones generated before birth persist and maintain high abundances in adult organisms for decades, slowly decaying with age.Our results suggest that large, low-diversity public clones are created during pre-natal life, and survive 3 Piece Outdoor Counter Height Dining Set over long periods, providing the basis of the public repertoire.